I forgot one side effect, The cartilage inside my nose is totally dissolved. From about a half inch up my nostril to the bone of my skull my nostrils connect. All the cartilage is gone. It started about 4 year into the drug. I can do a few trick of putting say a pea in one side and blowing it out the other. Great at parties. Ha Ha. I do worry that some day my nose is just going to cave into my face.